Leydig tumor in normal sized ovaries causing clitoromegaly: A case report

Area of Science:

• Gynecologic Oncology
• Endocrinology
• Pathology

Background:

• Leydig cell tumors are rare ovarian neoplasms, typically affecting premenopausal women and presenting with virilization.
• Bilateral ovarian involvement is exceptionally uncommon, particularly in postmenopausal individuals.

Observation:

• A 66-year-old postmenopausal woman presented with postmenopausal bleeding and acute clitoromegaly.
• Diagnostic workup revealed a left ovarian complex cyst and markedly elevated serum testosterone levels.

Findings:

• Pathological examination confirmed bilateral ovarian Leydig cell tumors.
• The tumors were associated with significant androgen overproduction.

Implications:

• This case highlights an atypical presentation of a rare ovarian tumor in a postmenopausal woman.
• It underscores the importance of comprehensive gynecological examination and hormonal investigation in cases of virilization.
• Early detection and management are crucial for favorable outcomes in rare gynecological malignancies.