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Updated: Jul 1, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Renal function alters the association of lipoprotein(a) with cardiovascular outcomes in patients undergoing
Guyu Zeng1, Pei Zhu1, Deshan Yuan1
1Department of Cardiology, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Elevated Lipoprotein(a) [Lp(a)] significantly increases cardiovascular risk in patients undergoing percutaneous coronary intervention (PCI), especially those with impaired renal function. Renal function mediates this association, highlighting the need for close monitoring in at-risk individuals.
Area of Science:
- Cardiology
- Nephrology
- Biomarkers
Background:
- Lipoprotein(a) [Lp(a)] and renal dysfunction are independent cardiovascular disease (CVD) risk factors.
- The role of renal function in mediating the Lp(a)-CVD outcome link in percutaneous coronary intervention (PCI) patients is unclear.
Purpose of the Study:
- To investigate whether renal function mediates the association between Lp(a) and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing PCI.
Main Methods:
- Analysis of 10,435 patients undergoing PCI, stratified by baseline estimated glomerular filtration rate (eGFR).
- Primary endpoint: composite of all-cause death, nonfatal MI, ischemic stroke, and unplanned revascularization (MACCE).
- Median follow-up of 5.1 years.
Main Results:
- Both reduced eGFR (<60 ml/min/1.73 m 2) and elevated Lp(a) were associated with higher MACCE risk.
- A significant interaction (P=0.026) showed Lp(a) risk was amplified in patients with eGFR <60 ml/min/1.73 m 2.
- Concomitant high Lp(a) and low eGFR predicted worse cardiovascular outcomes.
Conclusions:
- Renal function significantly mediates the association between Lp(a) and cardiovascular outcomes in PCI patients.
- Lp(a) confers a higher risk in patients with worse renal function.
- Close monitoring and aggressive management are crucial for patients with both elevated Lp(a) and impaired renal function.
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