Personalized Medicine in Brain Gliomas: Targeted Therapy, Patient-Derived Tumor Models (Review)

Area of Science:

• Neuro-oncology
• Cancer Therapeutics
• Genomics

Background:

• Gliomas represent the most prevalent primary malignant brain tumors.
• Traditional treatments for gliomas have historically yielded unsatisfactory outcomes.
• Recent advancements include personalized targeted therapies and patient-derived tumor models.

Purpose of the Study:

• To review the molecular and genetic mechanisms driving glioma growth.
• To evaluate the efficacy of personalized approaches versus standard therapies for gliomas.
• To highlight the role of patient-derived tumor models in predicting drug effectiveness.

Main Methods:

• Literature review of molecular and genetic mechanisms in glioma.
• Analysis of personalized targeted therapies for cancer treatment.
• Examination of patient-derived tumor models for drug screening.

Main Results:

• Personalized targeted therapies demonstrate higher efficacy compared to standard treatments for gliomas.
• Patient-derived tumor models show promise for testing diverse antitumor drugs.
• Predicting the effectiveness of specific drug regimens remains a challenge.

Conclusions:

• A personalized approach to glioma treatment shows superior efficacy.
• Patient-derived tumor models are crucial for advancing glioma drug discovery and selection.
• Further research is needed to fully leverage these models for clinical application.