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Updated: Jul 1, 2025

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Construction methods and biomedical applications of PVA-based hydrogels.

Yi Zhong1, Qi Lin1, Han Yu1

  • 1Zhejiang Key Laboratory of Pathophysiology, Department of Cell Biology and Regenerative Medicine, Health Science Center, Ningbo University, Ningbo, China.

Frontiers in Chemistry
|March 4, 2024
PubMed
Summary

Polyvinyl alcohol hydrogels offer biocompatibility and tunable properties for biomedical uses. This review covers their preparation and applications in areas like cartilage repair and wound dressings.

Keywords:
PVAarticular cartilage restorationelectronic skinhydrogelswound dressing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry

Background:

  • Polyvinyl alcohol (PVA) hydrogels are widely researched due to excellent biocompatibility, mechanical strength, and water content.
  • The hydroxyl groups on PVA enable functionalization for diverse properties.

Purpose of the Study:

  • To review the preparation methods of PVA-based hydrogels.
  • To highlight the broad biomedical applications of PVA hydrogels.

Main Methods:

  • Literature review of PVA hydrogel synthesis techniques.
  • Analysis of studies demonstrating PVA hydrogel properties and applications.

Main Results:

  • PVA hydrogels can be modified to achieve enhanced cytocompatibility, flexibility, conductivity, viscoelasticity, and antimicrobial activity.
  • Various synthesis and structural modifications are discussed.

Conclusions:

  • PVA hydrogels are versatile biomaterials with significant potential in articular cartilage restoration, electronic skin, and wound dressings.
  • Further development in synthesis and modification can expand their biomedical utility.