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Updated: Jul 1, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Cross-validated tree-based models for multi-target learning
Yehuda Nissenbaum1, Amichai Painsky1
1Department of Industrial Engineering, Tel Aviv University, Tel Aviv, Israel.
Abstract:
Multi-target learning (MTL) is a popular machine learning technique which considers simultaneous prediction of multiple targets. MTL schemes utilize a variety of methods, from traditional linear models to more contemporary deep neural networks. In this work we introduce a novel, highly interpretable, tree-based MTL scheme which exploits the correlation between the targets to obtain improved prediction accuracy. Our suggested scheme applies cross-validated splitting criterion to identify correlated targets at every node of the tree. This allows us to benefit from the correlation among the targets while avoiding overfitting. We demonstrate the performance of our proposed scheme in a variety of synthetic and real-world experiments, showing a significant improvement over alternative methods. An implementation of the proposed method is publicly available at the first author's webpage.
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