Calcium Blood Level Elevation After Atorvastatin Initiation in a Patient With Hyperparathyroidism

Area of Science:

• Endocrinology
• Pharmacology

Background:

• Atorvastatin is widely prescribed for hypercholesterolemia.
• Known adverse effects of atorvastatin do not typically include hypercalcemia.

Observation:

• A 52-year-old male with hyperparathyroidism and hypercholesterolemia experienced increased calcium levels while on atorvastatin.
• The patient was asymptomatic, and hypercalcemia was investigated as a potential drug adverse effect.

Findings:

• Discontinuation of atorvastatin led to a decrease in the patient's calcium levels.
• Readministration and subsequent cessation of atorvastatin confirmed its role in altering calcium levels.

Implications:

• This case suggests hypercalcemia may be a rare adverse effect of atorvastatin.
• Physicians should consider atorvastatin-induced hypercalcemia, especially in patients with pre-existing hypercalcemia or hyperparathyroidism.