Related Experiment Video
Updated: Jul 1, 2025
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Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
Published on: April 30, 2019
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Structure formation induced by non-reciprocal cell-cell interactions in a multicellular system.
Biplab Bhattacherjee1, Masayuki Hayakawa1, Tatsuo Shibata1
1Laboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima minamimachi, Chuo-ku, Kobe 650-0047, Japan. biplab.bhattacherjee@riken.jp.
Soft Matter
|March 4, 2024
Summary
Researchers discovered that force imbalance in cell chains propels collective cell migration. This finding, inspired by Dictyostelium discoideum mutant cells, led to a new theoretical model for cell movement.
Area of Science:
- Cellular Biology
- Biophysics
- Developmental Biology
Background:
- Collective cellular behavior is vital in development and disease.
- Previous work identified contact following locomotion (CFL) in Dictyostelium discoideum mutants.
Purpose of the Study:
- To investigate the forces driving collective cell migration in Dictyostelium discoideum mutants.
- To develop a theoretical model for non-reciprocal cell-cell interactions in collective migration.
Main Methods:
- Analysis of force imbalance within cell chains.
- Development of a theoretical model incorporating non-reciprocal interactions.
- Construction of a phase diagram for collective cell migration.
Main Results:
- Identified an imbalance of forces between front and rear cells, generating propulsion.
- Demonstrated that non-reciprocal interactions, alongside self-alignment, drive collective migration.
- Generated a phase diagram illustrating distinct migration phases.
Conclusions:
- Non-reciprocal cell-cell interactions are key to collective cell migration.
- The theoretical model accurately reflects experimental observations in Dictyostelium discoideum.
- Understanding these forces can inform studies on morphogenesis and metastasis.
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