Correlation between endometriosis and migraine features: Results from a prospective case-control study

Area of Science:

• Gynecology
• Neurology
• Pain Medicine

Background:

• Endometriosis and migraine frequently coexist, yet their association is understudied.
• Limited research exists on the link between headache features and endometriosis subtypes.

Purpose of the Study:

• To investigate the correlation between headache features and endometriosis subtypes in untreated women with comorbid endometriosis/adenomyosis and migraine.
• To explore the relationship between these conditions and pain severity and disease disability.

Main Methods:

• Fifty women with endometriosis/adenomyosis and migraine were compared to 100 with endometriosis alone and 100 with migraine alone.
• Pelvic ultrasound and neurological examinations were performed.

Main Results:

• Severe adenomyosis and deep infiltrating endometriosis were more frequent in women with migraine.
• Dysmenorrhea was common, and typical endometriosis symptoms had higher VAS scores with comorbidity.
• Women with both conditions reported higher pain intensity, more monthly migraine days, and increased HIT-6 scores.

Conclusions:

• Migraine comorbidity in women with endometriosis is associated with more severe gynecological infiltrations.
• This co-occurrence correlates with increased pain intensity and disease disability.