Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026

Same author

Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging.

Cell stem cell·2026

Same author

Effects of 5-Year Exercise Training on Cognition in Older Adults: 10-Years Follow-Up from the Generation 100 Study.

Sports medicine - open·2025

Same author

Longitudinal Associations between Cardiorespiratory Fitness and Cognition in Older Adults: A 10-Year Follow-Up from the Generation 100 Study.

Medicine and science in sports and exercise·2025

Same author

Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis.

Biomaterials·2025

Same author

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing.

Lancet (London, England)·2025

Same journal

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial).

Journal of visualized experiments : JoVE·2026

Same journal

A Standardized Ex Vivo Porcine Oromucosal Model for Evaluating Peptide Fluxes.

Journal of visualized experiments : JoVE·2026

Same journal

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026

Same journal

Integrating Artificial Intelligence-Assisted Translation Support into English Courses: Effects on Translation Accuracy, Perceived Stress, and Anxiety.

Journal of visualized experiments : JoVE·2026

Same journal

A Toxin-Based Counter-Selection System for Markerless Gene Deletion and High-Density Tn5 Transposon Mutagenesis in Pectobacterium brasiliense.

Journal of visualized experiments : JoVE·2026

Same journal

Seamless Multimodal Human-Robot Communication: Integration Techniques in Human-Computer Interaction.

Journal of visualized experiments : JoVE·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2025

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice.

Asad A Ali¹, Tara L Walker², Daniel G Blackmore³

¹Queensland Brain Institute, The University of Queensland.

Journal of Visualized Experiments : Jove

|March 4, 2024

Summary

This summary is machine-generated.

The active place avoidance (APA) task offers a versatile method for assessing spatial learning in rodents. This protocol details the APA task, highlighting its advantages for studying various cognitive functions and disease models.

More Related Videos

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Related Experiment Videos

Last Updated: Jul 1, 2025

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Area of Science:

Neuroscience
Behavioral Neuroscience
Cognitive Science

Background:

Hippocampus-dependent spatial learning is crucial for navigation.
Traditional methods like the Morris water maze (MWM) have limitations.
The active place avoidance (APA) task provides a novel approach.

Purpose of the Study:

To provide a detailed protocol for the active place avoidance (APA) task.
To highlight the versatility and advantages of the APA task.
To describe data collection and analysis for the APA task.

Main Methods:

Mice navigate a rotating arena with spatial cues.
Animals must avoid a stationary shock zone.
The APA task allows for adjustable parameters and longitudinal studies.

Main Results:

The APA task is adaptable for various mouse strains and conditions.
It is suitable for aged mice and disease models like Alzheimer's.
The task can accommodate animals with motor or neural impairments.

Conclusions:

The APA task is a flexible and powerful tool for spatial learning research.
It offers advantages over traditional methods for specific research questions.
This protocol facilitates the successful implementation of the APA task.