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The presence of autoantibodies as a potential prognostic biomarker for breast cancer

  • 0Department of Clinical Laboratory, People's Hospital of Henan University, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University, Zhengzhou, Henan, China.
Scandinavian Journal of Immunology +

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March 4, 2024

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March 4, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Autoantibodies show promise as biomarkers for breast cancer prognosis. Patients with autoantibodies had a significantly lower risk of death and longer survival, indicating their potential as a positive prognostic indicator.

Area Of Science

  • Oncology
  • Immunology
  • Biomarker Discovery

Background

  • Autoantibodies are linked to cancer development and can serve as early diagnostic markers for breast cancer.
  • The prognostic value of autoantibodies in breast cancer patients is not well understood.
  • This study investigates the association between autoantibodies and patient outcomes in breast cancer.

Purpose Of The Study

  • To determine the correlation between the presence of autoantibodies and the prognosis of breast cancer patients.
  • To identify autoantibodies as potential prognostic predictors for breast cancer.
  • To explore new strategies for prognostic assessment in breast cancer.

Main Methods

  • Retrospective analysis of 88 breast cancer patients diagnosed between January 2017 and December 2021.
  • Univariate and multivariate Cox regression analyses to identify risk factors for poor prognosis.
  • Kaplan-Meier curves to analyze the association between autoantibodies and patient survival.

Main Results

  • Autoantibody-positive breast cancer patients exhibited a 57% lower risk of death compared to autoantibody-negative patients.
  • Multivariate analysis confirmed autoantibody presence as an independent prognostic predictor, irrespective of clinical and pathological factors.
  • Autoantibody-positive patients demonstrated longer progression-free survival and overall survival.

Conclusions

  • The presence of autoantibodies is associated with a better prognosis in breast cancer patients.
  • Autoantibodies represent a novel, independent biomarker for improved prognostic assessment in breast cancer.
  • This finding offers a new strategy for evaluating breast cancer patient outcomes.

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