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Updated: Jul 1, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Dienes as Versatile Substrates for Transition Metal-Catalyzed Reactions
Amanda M Canfield1, Dasha Rodina1, Shauna M Paradine1
1Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY, 14627.
Abstract:
Dienes have been of great interest to synthetic chemists as valuable substrates due to their abundance and ease of synthesis. Their unique stereoelectronic properties enable broad reactivity with a wide range of transition metals to construct molecular complexity facilitating synthesis of biologically active compounds. In addition, structural diene variation can result in substrate-controlled reactions, providing valuable mechanistic insights into reactivity and selectivity patterns. The last decade has seen a wealth of new methodologies involving diene substrates through the power of transition metal catalysis. This review summarizes recent advances and remaining opportunities for transition metal-catalyzed transformations involving dienes.
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