Related Experiment Video
Updated: Jul 1, 2025
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Risk factors for mortality in Stenotrophomonas maltophilia bacteremia - a meta-analysis
Chienhsiu Huang1, Lichen Lin2, Sufang Kuo2
1Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan.
Background:
Stenotrophomonas maltophilia (S. maltophilia) is a nosocomial pathogen causing life-threatening invasive infections with a high mortality rate in some patient populations, especially those who are severely ill or immunocompromised. There is a need for data on mortality in patients with S. maltophilia bacteremia.
Objective:
In this meta-analysis, we aimed to investigate risk factors for mortality in S. maltophilia bacteremia.
Methods:
Studies comparing patients who died from S. maltophilia bacteremia with patients who survived were considered for inclusion. Studies were included if they reported one or more risk factors for mortality. Mortality risk factors included clinical predisposing factors, predisposing comorbidities and appropriateness of antibiotic therapy.
Results:
Nineteen studies with 1248 patients were included in the meta-analysis. Five hundred and six (40.5%) patients died. The following risk factors for mortality were identified: ICU admission, septic shock, need for mechanical ventilation, indwelling central venous catheter, neutropenia, comorbid hematological malignancies, chronic kidney disease, inappropriate antimicrobial therapy and prior antibiotic use.
Conclusions:
Appropriate antimicrobial therapy had a protective effect against mortality in S. maltophilia bacteremia. Indwelling central venous catheter, neutropenia, hematological malignancies and chronic kidney disease were also risk factors for mortality.
Insights
Stenotrophomonas maltophilia bacteremia is deadly, especially for ICU patients. Appropriate antibiotics protect against death, while central lines, neutropenia, and comorbidities increase risk.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Epidemiology
Background:
- Stenotrophomonas maltophilia (S. maltophilia) is a significant nosocomial pathogen.
- It causes severe invasive infections with high mortality in vulnerable populations.
- Data on mortality risk factors in S. maltophilia bacteremia is needed.
Conclusions:
- Appropriate antimicrobial therapy is crucial for reducing mortality in S. maltophilia bacteremia.
- Indwelling central venous catheters, neutropenia, hematological malignancies, and chronic kidney disease are significant risk factors.
- These findings highlight the importance of targeted interventions and optimal antibiotic selection.
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...