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Updated: Jul 1, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Impact of curcumin supplementation on exercise performance and muscle damage after a soccer match: a double-blind
Yoko Tanabe1,2,3, Emi Kondo4,5,6, Hiroyuki Sagayama7,4,6,8
1Department of Sport Research, Japan Institute of Sports Sciences, Tokyo, Japan. tanabe151@toyo.jp.
Purpose:
Curcumin ingestion can mitigate muscle damage, soreness, and inflammation following a laboratory-based eccentric exercise. Similar effects were observed in recent field-based studies wherein responses were evaluated after a soccer match. However, various potential confounding factors, such as matching opponent skill levels and daily training conditions, may have influenced the outcomes. In the present study, we investigated whether curcumin intake ameliorates changes in muscle damage markers following a soccer match while controlling for the potential confounding factors.
Methods:
Fifteen collegiate athletes were tested in a randomized, double-blind, cross-over manner. They were recruited from the same college soccer team and thus followed the same daily training regimen and competition levels. Furthermore, athletes positioning during matches were counterbalanced. They consumed either 180 mg/day of curcumin or a placebo starting 1 h before the match and continuing for 2 days after a match (two 45-min plays and a 15-min half-time). Muscle soreness, jump performance (including countermovement jump and rebound jump index), and inflammatory and muscle damage markers (high-sensitive C-reactive protein, serum creatine kinase activity, and urinary N-terminal fragment of titin concentration) were evaluated before and after the match. The washout period between matches was set at 1 week.
Results:
After the match, all markers showed similarity between the placebo and curcumin conditions (all P > 0.208).
Conclusion:
These findings indicate that ingesting 180 mg/day of curcumin may not expedite recovery from muscle damage elicited by soccer matches in collegiate soccer players.
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