Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

156
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
156
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Understanding Sleep01:11

Understanding Sleep

228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

143
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
143
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

1.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spin radical enhanced magnetocapacitance effect in intermolecular excited states.

The journal of physical chemistry. B·2013
Same author

Recent developments in stir bar sorptive extraction.

Analytical and bioanalytical chemistry·2013
Same author

Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.

ChemMedChem·2013
Same author

Magnetic polycarbonate microspheres for tumor-targeted delivery of tumor necrosis factor.

Drug delivery·2013
Same author

A study on validity of cortical alpha connectivity for schizophrenia.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
Same author

Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes.

Stem cell research·2013

Related Experiment Video

Updated: Jul 1, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.8K

Decreased structural pathways mediating functional connectivity in obstructive sleep apnea.

Xuerong Shi1, Guo Shen2, Ziyang Zhao1

  • 1Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou, 730000, China.

Sleep Medicine
|March 4, 2024
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) alters brain connectivity. Patients with OSA show reduced structural connectivity (SC) mediating functional connectivity (FC), impacting brain communication.

Keywords:
Functional connectivityMultilayer network analysisObstructive sleep apnea syndromePath tracingSC-FC bandwidthStructural connectivity

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

2.2K

Related Experiment Videos

Last Updated: Jul 1, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.8K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.4K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

2.2K

Area of Science:

  • Neuroimaging
  • Network Neuroscience
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is a prevalent sleep disorder.
  • OSA is associated with alterations in structural connectivity (SC) and functional connectivity (FC).
  • The interaction between SC and FC in OSA remains poorly understood.

Purpose of the Study:

  • To integrate neuroimaging modalities using multi-layer network analysis.
  • To investigate the complex interrelationships between SC and FC in OSA.
  • To introduce and apply a novel metric, SC-FC bandwidth, to quantify these interactions.

Main Methods:

  • Multi-layer network analysis was employed.
  • A new graph metric, SC-FC bandwidth, was introduced to measure SC's mediation of FC.
  • Network-based statistics (NBS) evaluated bandwidth differences between groups.
  • SC pathways associated with abnormal bandwidth were traced.

Main Results:

  • In both healthy controls and OSA patients, most synchronized nodes were connected via SC paths of length 2.
  • OSA patients exhibited significantly lower SC-FC bandwidth in specific brain regions (e.g., right Posterior cingulate gyrus, right Cuneus, bilateral Middle frontal gyrus, bilateral Gyrus rectus).
  • OSA patients showed decreased direct SC-FC, SC-FC triangles, and SC-FC quads within and between networks.

Conclusions:

  • Significant alterations in SC-FC interrelationships exist in OSA.
  • These changes may lead to abnormal information transmission and communication within the brain network in OSA patients.