Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

175
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
175
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

212
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
212
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

141
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
141
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

485
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
485
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

31.6K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Listeria survival dynamics on pears under real-world storage: effects of variety, production practice, storage, and decay.

Food microbiology·2026
Same author

Validation of sanitizer efficacy in commercial apple dump tanks using a Listeria monocytogenes surrogate.

Food microbiology·2026
Same author

Unearthing the bioactive properties of potato (<i>Solanum tuberosum</i>) for improving metabolic health.

Critical reviews in food science and nutrition·2026
Same author

Maternal obesity induces activator protein 1-mediated inflammatory response to impair embryonic neurogenesis.

The Journal of physiology·2026
Same author

Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Microbiota and free amino acid dynamics during aging of Cougar Gold cheese: insights into the puffy defects.

International journal of food microbiology·2025

Related Experiment Video

Updated: Jul 1, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
07:32

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

5.9K

α-Ketoglutarate for Preventing and Managing Intestinal Epithelial Dysfunction.

Alejandro Bravo Iniguez1, Min Du2, Mei-Jun Zhu1

  • 1School of Food Science, Washington State University, Pullman, WA, United States.

Advances in Nutrition (Bethesda, Md.)
|March 4, 2024
PubMed
Summary

α-Ketoglutarate (AKG) shows promise in maintaining intestinal barrier function. Supplementation may prevent gut epithelial dysfunction and support overall digestive health.

Keywords:
colorectal cancergut microbiomeinflammatory bowel diseaseintestinal healthα-ketoglutarate

More Related Videos

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.3K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

990

Related Experiment Videos

Last Updated: Jul 1, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
07:32

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

5.9K
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.3K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

990

Area of Science:

  • Gastroenterology and Nutritional Science
  • Molecular Biology and Metabolism

Background:

  • The intestinal epithelium is crucial for nutrient absorption, immune function, and barrier integrity.
  • Epithelial dysfunction contributes to inflammatory bowel disease and colorectal cancer.
  • Nutraceuticals are being explored to enhance intestinal epithelial homeostasis.

Purpose of the Study:

  • To review the scientific literature on α-ketoglutarate (AKG) for its potential in preventing intestinal epithelial dysfunction.
  • To highlight AKG's role as a metabolite with antioxidant, anti-inflammatory, and epigenetic cofactor activities.

Main Methods:

  • Literature review of studies on α-ketoglutarate and intestinal health.
  • Analysis of AKG's biochemical properties and known bioactivities.
  • Synthesis of findings related to AKG supplementation and epithelial integrity.

Main Results:

  • α-Ketoglutarate demonstrates antioxidant and anti-inflammatory properties relevant to gut health.
  • AKG acts as a cofactor for epigenetic modifications, influencing gene expression.
  • Evidence suggests AKG supplementation may protect against intestinal epithelial barrier disruption.

Conclusions:

  • α-Ketoglutarate holds significant potential as a nutraceutical for strengthening the intestinal epithelium.
  • Further research is warranted to fully elucidate AKG's therapeutic benefits for gut health and disease prevention.