Cancer associated fibroblasts-derived SULF1 promotes gastric cancer metastasis and CDDP resistance through the TGFBR3-mediated TGF-β signaling pathway
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View abstract on PubMed
Summary
This summary is machine-generated.Sulfentrase (SULF1) promotes gastric cancer metastasis and drug resistance by interacting with cancer-associated fibroblasts. Targeting the SULF1-TGF-β1 pathway offers new avenues for gastric cancer treatment and prognosis.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- Sulfentrase (SULF1) is implicated in various malignancies, but its role in gastric cancer remains unclear.
- Understanding SULF1's function is crucial for developing targeted gastric cancer therapies.
Purpose Of The Study
- To investigate the role and molecular mechanisms of SULF1 in gastric cancer.
- To explore SULF1's impact on tumor microenvironment interactions and patient prognosis.
Main Methods
- Analyzed SULF1 expression in gastric cancer tissues and correlated it with patient outcomes.
- Investigated the functional role of cancer-associated fibroblast (CAF)-derived SULF1 in gastric cancer cell metastasis and chemoresistance.
- Elucidated the molecular mechanism involving SULF1, TGF-β1, and TGFBR3 in intercellular communication.
Main Results
- SULF1 expression is elevated in gastric cancer, particularly in CAFs, and linked to poor prognosis.
- CAF-derived SULF1 promotes gastric cancer cell metastasis and cisplatin (CDDP) resistance.
- SULF1 acts as a signaling molecule, disrupting TGF-β1/TGFBR3 interaction and activating the TGF-β pathway.
Conclusions
- CAF-derived SULF1 is an oncogenic driver in gastric cancer.
- The CAF-SULF1-TGFBR3-TGF-β1 signaling axis represents a potential therapeutic target for gastric cancer.
- Targeting this axis may offer novel strategies for prognosis prediction and treatment.
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