High-mobility group box 1 and its related receptors: potential therapeutic targets for contrast-induced acute kidney

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An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury
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Changhua Mo1, Qili Huang1, Lixia Li1

  • 1Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region and Research Center of Cardiovascular Disease, Guangxi Academy of Medical Sciences, Nanning, China.

International Urology and Nephrology
|March 4, 2024
PubMed

Insights

Contrast agents used in percutaneous coronary intervention (PCI) can cause acute kidney injury (AKI). High-mobility group box 1 (HMGB1) may be a new therapeutic target for preventing contrast-induced AKI (CI-AKI).

Area of Science:

  • Nephrology
  • Cardiology
  • Molecular Biology

Background:

  • Percutaneous coronary intervention (PCI) is vital for coronary heart disease but carries a risk of contrast-induced acute kidney injury (CI-AKI).
  • CI-AKI significantly increases morbidity and mortality, with no current effective treatments.
  • Pathophysiological mechanisms include renal hypoxia, cellular stress, inflammation, and apoptosis.

Purpose of the Study:

  • To review the role of High-mobility group box 1 (HMGB1) in CI-AKI pathogenesis.
  • To explore HMGB1 as a potential therapeutic target for CI-AKI.

Main Methods:

  • Literature review of studies on CI-AKI and HMGB1.
  • Analysis of HMGB1 expression and function in renal injury models.
  • Examination of HMGB1 receptor interactions in the context of CI-AKI.

Main Results:

  • HMGB1 is implicated in the pathogenesis of various kidney diseases, including CI-AKI.
  • HMGB1 is released by damaged cells and activates inflammatory pathways via its receptors.
  • HMGB1 is expressed in multiple renal cell types involved in CI-AKI.

Conclusions:

  • HMGB1 plays a significant role in the development of CI-AKI.
  • Targeting HMGB1 presents a promising therapeutic strategy for preventing and treating CI-AKI.
  • Further research into HMGB1-targeted therapies is warranted for CI-AKI management.

Keywords:
Contrast-induced acute kidney injuryHigh-mobility group box 1Receptor for advanced glycation end productToll-like receptor

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