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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Mmp-11 Expression In Early Luminal Breast Cancer: Associations With Clinical, Mri, Pathological Characteristics, And Disease-free Survival.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Mmp-11 Expression In Early Luminal Breast Cancer: Associations With Clinical, Mri, Pathological Characteristics, And Disease-free Survival.

    • Related Experiment Video

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    MMP-11 expression in early luminal breast cancer: associations with clinical, MRI, pathological characteristics, and disease-free survival.

    Sébastien Molière1,2,3,4,5,6, Massimo Lodi7,8,9, Suzanne Leblanc10

    • 1Institute of Genetics and Molecular and Cellular Biology, Illkirch, France. sebastien.moliere@chru-strasbourg.fr.

    BMC Cancer
    |March 4, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Matrix metalloproteinase-11 (MMP-11) shows potential as an early prognostic marker in hormone-positive breast cancer. Its expression correlates with tumor grade and may predict disease-free survival, aiding in early cancer management.

    Keywords:
    Breast MRIBreast cancerImmunohistochemistryMMP-11MicroenvironmentRecurrence

    More Related Videos

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    Related Experiment Videos

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    Published on: August 1, 2018

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    Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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    Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
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    Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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    Area of Science:

    • Oncology
    • Biomarker Discovery
    • Breast Cancer Research

    Background:

    • Early hormone-positive breast cancers generally have good outcomes, but late recurrences necessitate long-term monitoring.
    • Matrix metalloproteinase-11 (MMP-11) is linked to poor prognosis in breast cancer, yet its role in early stages is under-explored.

    Purpose of the Study:

    • To investigate MMP-11 as an early prognostic marker in hormone-positive breast cancer.
    • To assess the association between MMP-11 expression and clinical, MRI, and survival data in early-stage disease.

    Main Methods:

    • Retrospective analysis of 228 women with early hormone-positive invasive ductal carcinoma treated surgically.
    • Immunohistochemistry used to measure MMP-11 expression.
    • Correlation analysis with clinical data, MRI features, and oncological outcomes.

    Main Results:

    • MMP-11 expression was detected in 50% of cases, correlating with higher uPA levels and tumor grade.
    • MMP-11 positivity showed specific associations with MRI findings.
    • Disease-free survival was associated with both Ki67 and MMP-11 levels over a 6.5-year follow-up.

    Conclusions:

    • MMP-11, found in stromal cells, correlates with tumor grade and uPA levels.
    • MMP-11 shows a trend towards association with disease-free survival, independent of Ki67.
    • MMP-11 holds promise as a valuable prognostic marker for managing early hormone-positive breast cancer.