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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

618
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
618
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

124
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
124
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

295
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
295
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

88
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
88
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

89
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
89
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

249
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
249
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Opioid Analgesia And Severity Of Acute Pancreatitis: An International Multicentre Cohort Study On Pain Management In Acute Pancreatitis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Opioid Analgesia And Severity Of Acute Pancreatitis: An International Multicentre Cohort Study On Pain Management In Acute Pancreatitis.

Related Experiment Video

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

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Opioid analgesia and severity of acute pancreatitis: An international multicentre cohort study on pain management in acute pancreatitis.

Sanjay Pandanaboyana1,2, Cecilie Siggaard Knoph3,4, Søren Schou Olesen3,4

  • 1HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, UK.

United European Gastroenterology Journal
|March 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Opioid use in acute pancreatitis patients increases severity risk when given after admission or for extended periods. Further research is needed to confirm opioid safety in acute pancreatitis management.

Keywords:
acute pancreatitisalcoholicanalgesiamorbidity

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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

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Related Experiment Videos

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

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Area of Science:

  • Gastroenterology
  • Clinical Pharmacology
  • Epidemiology

Background:

  • The impact of pain management on acute pancreatitis outcomes is not well understood.
  • Preclinical studies suggest potential risks associated with opioid administration in acute pancreatitis.

Purpose of the Study:

  • To investigate the association between analgesic use, specifically opioids, and the severity and mortality of acute pancreatitis.
  • To evaluate the safety of different opioid administration strategies in hospitalized acute pancreatitis patients.

Main Methods:

  • A prospective, multicenter cohort study involving 1768 patients with a first episode of acute pancreatitis.
  • Data collection included aetiology, clinical course, and analgesic treatment over a 1-month follow-up period.
  • Primary outcome analysis focused on the relationship between opioid analgesia and pancreatitis severity using univariate and multivariate models.
mortality
opioid
pain
severity

Main Results:

  • Opioid administration after admission day (OR 2.07) and treatment duration of 6 days or more (OR 3.21) were independently associated with increased risk of moderately severe or severe acute pancreatitis.
  • Univariate analysis indicated a link between longer opioid duration and mortality.
  • Factors like male sex, Asian ethnicity, alcohol aetiology, comorbidity, and higher pain scores were also associated with severe pancreatitis.

Conclusions:

  • Opioid administration after admission or for prolonged durations (≥6 days) elevates the risk of severe acute pancreatitis.
  • The findings suggest a need for careful consideration of opioid timing and duration in acute pancreatitis management.
  • Further randomized controlled trials are recommended to definitively assess opioid safety in this patient population.