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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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Major depressive disorder and the risk of irritable bowel syndrome: A Mendelian randomization study

Ruiming Zhu1, Nan Zhang1, He Zhu1

  • 1Department of Endoscopy, The First Hospital of Jilin University, Changchun, Jilin, China.

Molecular Genetics & Genomic Medicine
|March 5, 2024
PubMed
Abstract

Insights

Major depressive disorder (MDD) may causally increase the risk of developing irritable bowel syndrome (IBS). This genetic study provides evidence supporting a link between MDD and IBS, impacting patient care.

Area of Science:

  • Psychiatry and Gastroenterology
  • Genetic Epidemiology
  • Causal Inference

Background:

  • Observational studies suggest an association between Major Depressive Disorder (MDD) and Irritable Bowel Syndrome (IBS).
  • The causal relationship between MDD and IBS remains unclear.
  • This study investigates the potential causal effect of MDD on IBS using genetic data.

Conclusions:

  • Findings support a causal relationship between Major Depressive Disorder (MDD) and Irritable Bowel Syndrome (IBS).
  • This causal link has potential implications for the clinical management of IBS in patients with MDD.
Keywords:
Mendelian randomizationirritable bowel syndromemajor depressive disorder

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