Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Interactions: Mutualism01:25

Microbial Interactions: Mutualism

Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through this...
Microbial Interactions: Cooperation01:26

Microbial Interactions: Cooperation

Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhalation airflow and ventilation efficiency in subject-specific human upper airways.

Respiratory physiology & neurobiology·2020
Same author

Adverse Effects of Low-Dose Methotrexate in a Randomized Double-Blind Placebo-Controlled Trial: Adjudicated Hematologic and Skin Cancer Outcomes in the Cardiovascular Inflammation Reduction Trial.

ACR open rheumatology·2020
Same author

Preparation and <i>in Vitro</i> Antitumor Study of Two-Dimensional Muscovite Nanosheets.

Langmuir : the ACS journal of surfaces and colloids·2020
Same author

Identification and Bioinformatic Assessment of circRNA Expression After <i>RMI1</i> Knockdown and Ionizing Radiation Exposure.

DNA and cell biology·2020
Same author

Pollution haven or halo? The role of the energy transition in the impact of FDI on SO2 emissions.

The Science of the total environment·2020
Same author

Efficacy and Safety of Bevacizumab Plus Oxaliplatin- or Irinotecan-Based Doublet Backbone Chemotherapy as the First-Line Treatment of Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis.

Drug safety·2020

Related Experiment Video

Updated: Jun 5, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

22.4K

Christensenella minuta interacts with multiple gut bacteria.

Chang Xu1, He Jiang1, Li-Juan Feng1

  • 1State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.

Frontiers in Microbiology
|March 5, 2024
PubMed
Summary

Christensenella minuta (C. minuta) alters gut microbiota composition by cross-feeding beneficial bacteria and compensating for its own metabolic needs. This probiotic intervention impacts microbial diversity and specific bacterial populations, offering insights into host health.

Keywords:
ChristensenellaceaeFaecalibacterium prausnitziiKlebsiella pneumoniaeco-occurrence networkintestinal microorganismnutrient cross-feeding

More Related Videos

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

11.6K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
00:06

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.0K

Related Experiment Videos

Last Updated: Jun 5, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

22.4K
Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

11.6K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
00:06

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.0K

Area of Science:

  • Microbiology
  • Gut Microbiome Research
  • Probiotic Science

Background:

  • Gut microbes significantly influence host health and disease treatment.
  • Christensenella minuta (C. minuta) is a next-generation probiotic regulating energy balance and metabolic homeostasis.
  • Interactions of C. minuta with the gut microbial network are not well understood.

Purpose of the Study:

  • To investigate the impact of C. minuta on fecal microbiota composition.
  • To explore the interactions between C. minuta and other gut bacteria.
  • To understand the mechanisms by which C. minuta modulates the gut microbial network.

Main Methods:

  • Metagenomic sequencing of fecal microbiota.
  • Coculture assays of C. minuta with associated microbial partners.
  • Analysis of bacterial strain interactions and metabolic pathways.

Main Results:

  • C. minuta intervention reduced overall fecal microbial diversity but enriched specific bacteria like Lactobacillaceae.
  • C. minuta compensated for its metabolic deficiencies by utilizing pathways for vitamin and amino acid synthesis.
  • C. minuta cross-fed Faecalibacterium prausnitzii and inhibited Klebsiella pneumoniae, demonstrating selective microbial modulation.

Conclusions:

  • C. minuta disrupts gut microbiota composition through cross-feeding and metabolic interactions.
  • These interactions lead to the enrichment or inhibition of specific bacterial growth.
  • C. minuta shows potential as a probiotic for gut microbiome interventions and improving host health.