Related Experiment Video
Updated: Jul 1, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.9K
Poor adherence to and persistence with biologics in generalized pustular psoriasis: A claim-based study using
Steven R Feldman1, Rhonda L Bohn2, Ran Gao3
1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
JAAD International
|March 5, 2024
Summary
Adherence and persistence to biologics for generalized pustular psoriasis (GPP) were generally poor in a US study. Improving patient adherence is crucial for better GPP treatment outcomes.
Area of Science:
- Dermatology
- Pharmacoeconomics
- Real-world evidence
Background:
- Generalized pustular psoriasis (GPP) is a rare, severe dermatological condition.
- Characterized by episodes of widespread sterile pustules, GPP significantly impacts patient quality of life.
Purpose of the Study:
- To evaluate adherence and persistence to biologic therapies in patients diagnosed with GPP.
- To identify factors influencing biologic treatment adherence and persistence in a real-world setting.
Main Methods:
- Retrospective cohort study utilizing US MarketScan and Optum databases (October 2015 - March 2020).
- Included patients aged 18+ with newly diagnosed GPP (ICD code L40.1) and specific healthcare claim criteria.
- Analyzed biologic dispensing, proportion of days covered (PDC) for adherence, and treatment duration for persistence.
Main Results:
- Biologics were used by 14-22% of GPP patients across databases.
- Good adherence (≥80% PDC) was uncommon (24-36%), with mean PDC of 59-65%.
- Mean persistence was 261-287 days; younger adults (18-64) showed higher adherence and longer persistence than older adults (≥65).
Conclusions:
- Adherence and persistence to biologics in GPP patients were generally suboptimal.
- Treatment outcomes may be improved by enhancing patient adherence to biologic therapies.
- Adherence and persistence varied by biologic class, data source, and patient age.
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