Related Experiment Video
Updated: Jul 1, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic Gastroenteritis Causing Pyloric Stenosis: A Rare Manifestation
Fei Yang Pan1, Matthew Smale1, Michael Rennie1
1Department of Gastroenterology, Wollongong Hospital, Wollongong, NSW, Australia.
This case study details a rare instance of eosinophilic gastritis causing critical pyloric stenosis in an adolescent. Treatment involved surgery and long-term immunosuppression after steroids failed.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Immunology
Background:
- Eosinophilic gastritis is a rare gastrointestinal condition involving eosinophil buildup in the stomach wall.
- Pyloric stenosis, a narrowing of the stomach's exit, can cause severe digestive issues.
Observation:
- A 16-year-old girl presented with nausea, vomiting, early satiety, and abdominal pain.
- Imaging and endoscopy confirmed pyloric stenosis, but eosinophilic gastritis diagnosis was difficult.
Findings:
- High-dose corticosteroids were ineffective in treating the condition.
- A laparoscopic gastrojejunostomy was surgically performed.
- Long-term immunosuppression with mycophenolate mofetil was initiated.
Implications:
- This case highlights the diagnostic challenges of eosinophilic gastritis.
- It demonstrates the need for surgical intervention and immunosuppression in refractory cases.
- Highlights a rare cause of pediatric pyloric stenosis.
Related Concept Videos
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:

