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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Significance Of Systemic Inflammatory Markers In Prognosis Of Head And Neck Squamous Cell Cancers.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Significance Of Systemic Inflammatory Markers In Prognosis Of Head And Neck Squamous Cell Cancers.

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The Significance of Systemic Inflammatory Markers in Prognosis of Head and Neck Squamous Cell Cancers.

Bhushan Lal1, Diksha Thakur1, Payal Gupta1

  • 1Department of Otorhinology, Indra Gandhi Medical College & Hospital, Shimla, Himachal Pradesh India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|March 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Systemic inflammation markers, neutrophilic to lymphocytic ratio (NLR) and platelet to lymphocytic ratio (PLR), predict prognosis in head and neck cancer. Elevated NLR and PLR indicate poor outcomes and potential disease recurrence.

Keywords:
Head and neck cancerNeutrophilic to lymphocytic ratioPlatelet to lymphocytic ratio

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Area of Science:

  • Oncology
  • Inflammation Biomarkers
  • Head and Neck Cancer Prognostics

Background:

  • Head and neck squamous cell carcinoma (HNSCC) poses significant treatment challenges.
  • Accurate prognostic markers are crucial for effective patient management.
  • Systemic inflammatory responses are increasingly recognized as important in cancer progression.

Purpose of the Study:

  • To evaluate the predictive significance of neutrophilic to lymphocytic ratio (NLR) and platelet to lymphocytic ratio (PLR) in HNSCC prognosis.
  • To determine if these inflammatory markers can predict residual or recurrent disease.
  • To assess the utility of NLR and PLR at different time points post-diagnosis.

Main Methods:

  • A cohort of 47 histopathologically confirmed HNSCC patients (age >18) was prospectively monitored for 18 months.
  • Blood samples were analyzed to calculate NLR and PLR at baseline and follow-up intervals.
  • Statistical analysis was performed to correlate NLR and PLR levels with disease recurrence and residual disease.

    • Main Results:

    • Elevated platelet to lymphocytic ratio (PLR) at 6 months significantly predicted residual/recurrent disease (p < 0.0001).
    • Significantly higher neutrophilic to lymphocytic ratio (NLR) was observed in patients with recurrence at 12 months (p = 0.025).
    • No significant associations were found for NLR and PLR at the 18-month mark or for PLR at 12 months.

    Conclusions:

    • Elevated NLR and PLR are potential indicators of poor prognosis in HNSCC.
    • These markers may help identify patients at higher risk of residual or recurrent disease.
    • Further research with larger cohorts is warranted to validate these findings.