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Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder
Toshiharu Morikawa1, Shoichiro Iwatsuki1, Aya Naiki-Ito2
1Department of Nephro-Urology Graduate School of Medical Sciences, Nagoya City University Nagoya Japan.
Introduction:
The bladder exstrophy-epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment.
Case Presentation:
We report the case of a 44-year-old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy-epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment.
Conclusion:
This is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy-epispadias complex.
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