Neoadjuvant Immune Checkpoint Inhibitors in hepatocellular carcinoma: a meta-analysis and systematic review
Chunhong Tian1, Yifan Yu1, Yuqing Wang1
1The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in Immunology
|March 5, 2024
Summary
Neoadjuvant immunotherapy shows promise for resectable hepatocellular carcinoma (HCC), with significant pathological response rates. Further high-quality studies are needed to confirm efficacy and safety of different treatment regimens.
Area of Science:
- Oncology
- Immunotherapy
- Hepatocellular Carcinoma Research
Background:
- Standardized protocols for neoadjuvant immunotherapy in hepatocellular carcinoma (HCC) are lacking.
- Neoadjuvant immunotherapy has shown benefits in other cancer types.
- Investigating neoadjuvant immunotherapy's role in resectable HCC is crucial.
Conclusions:
- Neoadjuvant immunotherapy is a beneficial treatment for resectable HCC.
- Dual ICI combination therapy shows higher efficacy but increased toxicity.
- High-quality, large-scale studies are required for definitive conclusions.
Keywords:
hepatocellular carcinoma (HCC)immunotherapymeta-analysisneoadjuvantresectablesystematic reviewMore Related Videos
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