Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial
Xuechao Wang1, Junjie Feng1, Shaohua Luan2
1Department of Psychology, Handan Central Hospital, Handan, 056002, China.
Biomarkers in Medicine
|March 5, 2024
Summary
CDC42 protein levels correlate with improved mental health and quality of life in ST-elevation myocardial infarction patients after percutaneous coronary intervention, linked to specific T-cell subset changes.
Area of Science:
- Immunology
- Cardiology
- Psychiatry
Background:
- ST-elevation myocardial infarction (STEMI) significantly impacts patient quality of life and mental well-being.
- T-cell subsets play a crucial role in immune regulation and have been implicated in cardiovascular disease and mental health.
- The role of CDC42, a key regulator of cell polarity and actin dynamics, in the context of STEMI and associated psychological outcomes is not well understood.
Purpose of the Study:
- To examine the relationship between CDC42 levels and T-cell subsets (Th1, Th2, Th17, Treg).
- To investigate the association of CDC42 and T-cell ratios with anxiety, depression, and quality of life in STEMI patients undergoing percutaneous coronary intervention (PCI).
Main Methods:
- Sera from 156 STEMI patients undergoing PCI were analyzed.
- CDC42 protein levels were quantified.
- Frequencies of Th1, Th2, Th17, and Treg cells were determined.
- Correlations with anxiety, depression, and quality of life measures (EQ-5D, EQ-VAS) were assessed.
Main Results:
- CDC42 levels showed a negative correlation with Th1/Th2 and Th17/Treg ratios.
- Higher CDC42 levels were associated with lower anxiety and depression scores.
- CDC42 correlated positively with the EuroQol visual analog scale (EQ-VAS) score, indicating better quality of life.
- The Th17/Treg ratio was positively associated with anxiety and depression and negatively with EQ-VAS.
- The Th1/Th2 ratio was positively related to the EQ-VAS score.
Conclusions:
- CDC42 is linked to a modulation of T-cell subset balance in STEMI patients.
- Reduced Th1/Th2 and Th17/Treg ratios, associated with higher CDC42, correlate with improved psychological status and quality of life post-PCI.
- These findings suggest CDC42 as a potential biomarker for mental health and quality of life outcomes in STEMI patients.
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