Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate

Area of Science:

• Neurology
• Cardiology
• Pathophysiology

Background:

• Cardiovascular diseases (CVDs) and neurological diseases (NDs) are leading causes of global mortality and morbidity.
• CVDs claim 17.9 million lives annually, while NDs cause 6.8 million deaths each year.
• Neurologic manifestations of cardiovascular illness, such as stroke, severely diminish patients' quality of life.

Purpose of the Study:

• To investigate the mechanistic and molecular connections between cardiovascular disorders and neurological disorders.
• To highlight the association between cardiovascular and neurological diseases, focusing on specific neurodegenerative conditions.

Main Methods:

• Literature review of existing research on cardiovascular and neurological disease comorbidities.
• Analysis of studies examining the shared pathways and molecular underpinnings.
• Synthesis of findings linking cardiovascular health to neurodegenerative disease progression.

Main Results:

• Established links between cardiovascular dysfunction and increased risk/progression of neurodegenerative diseases.
• Identified common pathophysiological mechanisms, including inflammation, oxidative stress, and endothelial dysfunction.
• Highlighted the impact of cardiovascular risk factors on neurological disease onset and severity.

Conclusions:

• Understanding the cardiovascular-neurological axis is critical for comprehensive disease management.
• Therapeutic strategies targeting cardiovascular health may offer neuroprotective benefits.
• Further research into shared mechanisms can reveal novel treatment targets for both CVDs and NDs.