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Nanotheranostics: A Cutting-edge Technology for Cancer Management
Shwetapadma Dash1, Shasank Sekhar Swain1, Auromira Khuntia1,2
1Institute of Life Sciences, Nalco Square, Odisha, India.
Current Pharmaceutical Biotechnology
|March 5, 2024
Summary
Nanotheranostics offer a dual approach for cancer diagnosis and treatment, improving drug delivery and imaging. Further research is needed to overcome challenges in tumor heterogeneity and safety for clinical application.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Cancer remains a leading cause of death, with rising mortality due to recurrence and metastasis.
- Conventional diagnostics and therapeutics show limitations in effectively managing advanced cancer.
- Nanotheranostics present a promising integrated platform for enhanced cancer management.
Purpose of the Study:
- To review current nanodiagnostic and nanotherapeutic platforms for cancer.
- To summarize nanotheranostic candidates currently in clinical trials.
- To identify challenges and limitations hindering the clinical translation of nanotheranostics.
Main Methods:
- Comprehensive literature review of nanotheranostic platforms and clinical trial data.
- Analysis of nanotheranostic properties including solubility, targeting, imaging, and drug delivery.
- Evaluation of existing challenges such as tumor heterogeneity, safety, and regulatory hurdles.
Main Results:
- Nanotheranostic platforms demonstrate potential for improved cancer diagnosis and treatment.
- Several nanotheranostic agents (e.g., AGuIX®, NBTXR3) are in clinical trials.
- Key limitations include tumor heterogeneity, safety concerns, and regulatory complexities.
Conclusions:
- Nanotheranostics offer a versatile approach to simultaneously diagnose and treat cancer.
- Overcoming translational challenges is crucial for realizing the full potential of nanotheranostics.
- Continued research is vital for advancing nanotheranostics in clinical oncology.
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