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Related Concept Videos

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Related Experiment Video

Updated: Jul 1, 2025

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Causal link between gut microbiome and schizophrenia: a Mendelian randomization study.

Qi Zeng1, Min Zhang, Renxi Wang

  • 1Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

Psychiatric Genetics
|March 5, 2024
PubMed
Summary

This study found that certain gut bacteria, like Bacteroidales_S24-7 and Prevotellaceae, may increase schizophrenia risk. Conversely, Lachnospiraceae, Lactobacillaceae, and Verrucomicrobiaceae may reduce schizophrenia risk, suggesting gut microbiome regulation as a potential therapy.

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Area of Science:

  • Genetics
  • Microbiology
  • Psychiatry

Background:

  • Observational studies indicate altered gut microbiome composition in schizophrenia patients.
  • A genetic link between gut microbiota and schizophrenia remains to be fully elucidated.

Purpose of the Study:

  • To investigate the potential causal relationship between specific gut microbiome compositions and schizophrenia using a genetic approach.
  • To identify specific bacterial taxa that may influence schizophrenia risk through genetic predisposition.

Main Methods:

  • A two-sample Mendelian randomization (MR) study was employed.
  • Utilized 28 genetic instrumental variants associated with gut microbiome from recent reports and large-scale schizophrenia GWAS data.

Main Results:

  • Genetically elevated Bacteroidales_S24-7 and Prevotellaceae were associated with an increased risk of schizophrenia.
  • Genetically elevated Lachnospiraceae, Lactobacillaceae, and Verrucomicrobiaceae were associated with a reduced risk of schizophrenia.
  • No significant causal associations were found for the remaining 23 gut microbiome taxa.

Conclusions:

  • Specific gut bacteria have a genetically influenced causal effect on schizophrenia risk.
  • Targeting and regulating the gut microbiota could offer novel therapeutic strategies for schizophrenia management.