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Updated: Jul 1, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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Evolutionary divergence of TLR9 through ancestral sequence reconstruction

Manisha Ghosh1, Surajit Basak2, Shanta Dutta3

  • 1Division of Bioinformatics, ICMR-National Institute of Cholera and Enteric Diseases, P-33, C.I.T Road, Scheme-XM, Beliaghata Kolkata, 700010, India.

Immunogenetics
|March 5, 2024
PubMed
Summary

Toll-like receptors (TLRs) are key to innate immunity. This study reveals unique evolutionary patterns in mammalian TLR9, driven by sequence features and gradual mutations, differentiating it from other TLRs.

Keywords:
Ancestral sequenceDiversityEvolutionMutationPhylogenetic treeTLR

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