Regional lymph node evaluation in pediatric conventional melanoma subtype: a single-center 10-year review
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Sentinel lymph node biopsy (SLNB) is crucial for pediatric melanoma, as positive results and older age at diagnosis predict recurrence. Completion lymph node dissection (CLND) showed no significant benefit.
Area Of Science
- Pediatric Oncology
- Dermatology
- Surgical Oncology
Background
- Conventional melanoma (CM) in children requires understanding prognostic factors.
- Sentinel lymph node biopsy (SLNB) is a key staging procedure.
- Completion lymph node dissection (CLND) is a subsequent surgical option.
Purpose Of The Study
- To evaluate the prognostic and therapeutic impact of SLNB and CLND in pediatric CM.
- To identify predictive factors for outcomes in pediatric melanoma patients.
Main Methods
- Retrospective analysis of medical records from 2009-2020.
- Inclusion of patients aged 18 or younger with localized cutaneous CM.
- Analysis of metastasis detection rates, relapse risk, disease-free survival (DFS), and overall survival (OS).
Main Results
- SLNB detected metastasis in 57.6% of pediatric CM cases.
- Positive SLN status was linked to a significantly higher relapse risk (HR 5.92, P=0.024).
- Age at diagnosis correlated with recurrence risk (21% hazard increase per year).
Conclusions
- Positive SLN status and older age at diagnosis are associated with worse DFS in pediatric CM.
- CLND did not demonstrate prognostic or therapeutic value in this cohort.
- Further multicenter trials are recommended to validate these findings.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
