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Updated: Jul 1, 2025

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Unveiling NUSAP1 as a common gene signature linking chronic HBV infection and HBV-related HCC

Jiao Meng1, Zhenkun Yang1, Xinyi Jiang2

  • 1Department of Laboratory Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, Jiangsu, China.

Discover Oncology
|March 5, 2024
PubMed

Insights

Hepatitis B virus (HBV) infection can lead to liver cancer. Researchers identified NUSAP1 as a key gene promoting cancer growth and inhibiting cell death, indicating it

Area of Science:

  • Hepatology
  • Oncology
  • Bioinformatics

Background:

  • Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC).
  • Mechanisms driving HBV infection progression to HCC are not fully understood.
  • Identifying key molecular players is crucial for understanding HBV-related HCC pathogenesis.

Purpose of the Study:

  • To identify a hub gene connecting chronic HBV infection (CHB) and HBV-related HCC.
  • To elucidate the role of this hub gene in liver cancer progression.

Main Methods:

  • Bioinformatic analysis of gene expression datasets (GEO database).
  • Identification of differentially expressed genes (DEGs) and pathway enrichment (GO, KEGG).
  • Protein-protein interaction (PPI) network analysis (Cytoscape) to screen hub genes.
  • Prognostic assessment and functional experiments (cell growth, apoptosis) for validation.

Main Results:

  • NUSAP1 was found to be upregulated in both CHB and HBV-HCC patients.
  • High NUSAP1 expression is an independent predictor of poor prognosis in liver cancer.
  • NUSAP1 promotes cell proliferation, cell cycle progression, and inhibits apoptosis in liver cancer cells.

Conclusions:

  • NUSAP1 is a significant prognostic indicator for liver cancer.
  • NUSAP1 plays a critical role in HBV-HCC progression by enhancing cell proliferation and reducing apoptosis.
Abstract

Keywords:
Cell cycleChronic HBV infectionHepatocellular carcinomaNUSAP1

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