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Published on: May 25, 2017
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Recurrent alcohol-associated hepatitis is common and is associated with increased mortality
Jordi Gratacós-Ginès1,2,3, Pilar Ruz-Zafra4, Miriam Celada-Sendino5
1Department of Liver Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.
Hepatology (Baltimore, Md.)
|March 5, 2024
Summary
Recurrent alcohol-associated hepatitis (RAH) is common and more severe, increasing mortality. Patients surviving alcohol-associated hepatitis (AH) need intensive therapy for alcohol use disorder to prevent RAH.
Area of Science:
- Hepatology
- Gastroenterology
- Addiction Medicine
Background:
- Alcohol-associated hepatitis (AH) survivors frequently relapse.
- Clinical features, risk factors, and outcomes of recurrent AH (RAH) are not well defined.
Purpose of the Study:
- To investigate the incidence, risk factors, clinical course, and prognostic implications of RAH.
Main Methods:
- A registry-based study of 1118 patients with AH across 28 Spanish hospitals (2014-2021).
- Cox regression analysis for risk factors.
- Kaplan-Meier curves and log-rank tests for survival analysis.
Main Results:
- 11% of patients developed RAH (incidence 22% in those resuming alcohol use).
- Risk factors for RAH included age <50, heavy alcohol use, and prior liver decompensation.
- RAH cases were more severe (higher MELD, more ACLF/HE) and associated with lower abstinence rates and higher long-term mortality (39% vs. 21%).
Conclusions:
- Recurrent alcohol-associated hepatitis is common, clinically aggressive, and significantly increases mortality.
- Intensified alcohol use disorder therapy is crucial for AH survivors to prevent RAH.
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