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Related Experiment Video

Updated: Jul 1, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Published on: April 21, 2023

Current methods for hyperpolarized [1-¹³C]pyruvate MRI human studies.

Peder E Z Larson^1,2, Jenna M L Bernard¹, James A Bankson³

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Magnetic Resonance in Medicine

|March 5, 2024

Summary

This summary is machine-generated.

Hyperpolarized (HP) ¹³C MRI uses specialized agents to measure metabolism in diseases like cancer. This guide details best practices for human studies using HP ¹³C-pyruvate MRI.

Keywords:

carbon‐13 dissolution dynamic nuclear polarization hyperpolarized MRI metabolic imaging pyruvate

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Area of Science:

Medical Imaging
Metabolic Imaging
Hyperpolarized MRI

Background:

Hyperpolarized (HP) ¹³C MRI measures localized metabolism altered in diseases.
Human studies have grown rapidly in the last decade due to improved HP agent preparation.
¹³C-pyruvate is the most common agent, crucial for studying glycolysis.

Purpose of the Study:

To outline current successful practices for human HP ¹³C MRI studies.
Focuses on [1-¹³C]pyruvate, a key metabolic tracer.
To provide a comprehensive reference for the advancing field of metabolic imaging.

Main Methods:

Covers HP ¹³C-pyruvate preparation methods.
Details MRI system setup and calibration protocols.
Explains data acquisition, image reconstruction, and analysis techniques.

Main Results:

Identifies key components for successful HP ¹³C MRI studies.
Summarizes published studies and current clinical practices.
Discusses evidence gaps, strengths, and limitations of the modality.

Conclusions:

Establishes a consensus on best practices for human HP ¹³C MRI.
Aims to guide future research and development in metabolic imaging.
Highlights the potential of HP ¹³C MRI for diagnosing and monitoring various diseases.