Related Experiment Video
Updated: Jul 1, 2025
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Inflammatory and Nutritional Biomarkers in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant
Chun Hou Huang1, Bee Song Chang2, Tai-Chu Peng1
1Tzu Chi University.
Objectives:
To investigate the relationship between pretreatment inflammatory and nutritional biomarkers in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy and radiation therapy (nCRT).
Sample & Setting:
213 patients with newly diagnosed stage II-III ESCC who received nCRT at an academic hospital in Taiwan.
Methods & Variables:
Electronic health record data were used. Records on inflammatory and nutritional biomarkers and clinical outcomes were extracted. Logistic regression analysis was used to predict treatment-related adverse events, Cox regression was used for survival outcomes, and receiver operating characteristic curve analysis was used to determine optimal cutoff values.
Results:
There was a significant association between low prognostic nutritional index (PNI) and nCRT toxicities and survival. Advanced cancer stage, high platelet-to-lymphocyte ratio, and occurrence of pneumonia/infection were linked to survival outcomes.
Implications For Nursing:
PNI shows promise in predicting prognosis, helps identify high-risk patients, and enables nurses to apply tailored interventions.
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