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Related Concept Videos

Patch Clamp01:18

Patch Clamp

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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Related Experiment Video

Updated: Jul 1, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Published on: June 1, 2012

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3D Printed Ion-Responsive Personalized Transdermal Patch.

D Zhu1, X Peng1, L Li1

  • 1Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

ACS Applied Materials & Interfaces
|March 5, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces 3D printed microneedle patches that conform to skin's curves for improved drug delivery. The patches utilize gold nanoparticles and a novel prepolymer for precise fabrication and controlled release.

Keywords:
3D printingmicroneedlephotopolymerizationphotothermal heatingtransdermal patch

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery Systems

Background:

  • Microneedle patches offer efficient transdermal drug administration.
  • Challenges exist in achieving sufficient microneedle insertion on contoured skin due to planar patch designs.
  • This limits the efficacy of transdermal drug delivery systems.

Purpose of the Study:

  • To develop a high-fidelity, 3D printable prepolymer for personalized transdermal microneedle patches.
  • To enhance microneedle patch adhesion and drug delivery on curved skin surfaces.
  • To investigate controlled and sustainable drug release mechanisms.

Main Methods:

  • Formulation of a novel prepolymer for 3D printing.
  • Fabrication of microneedle patches using 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine (Tz) photoinitiator.
  • Incorporation of gold nanoparticles (AuNPs) for photothermal heating and sweat induction.
  • Analysis of ion-induced network rearrangement for patch curvature adaptation.
  • Evaluation of drug release kinetics.

Main Results:

  • Successful high-fidelity 3D printing of precise microneedle patches.
  • AuNPs induced photothermal heating and sweat production, leading to ion-induced patch curvature.
  • Alkanethiol-stabilized AuNPs enabled controlled drug release.
  • Photothermal heating of AuNPs enhanced sustained drug release.

Conclusions:

  • The developed prepolymer is suitable for creating personalized transdermal microneedle patches.
  • The patches demonstrate improved adhesion and drug delivery on body surfaces.
  • This technology holds promise for advanced transdermal therapeutic systems.