Related Experiment Video

Updated: Jul 1, 2025

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
09:24

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

9.1K

Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment

Jingyi Liang1, Meng Yu2, Yunong Li1

  • 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China; Liaoning Province, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning Province 110122, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 5, 2024
PubMed

Insights

Glycogen synthase kinase-3 (GSK-3) plays a key role in cancer progression and immune cell interactions within the tumor microenvironment. Novel GSK-3 inhibitors show promise for cancer immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Glycogen synthase kinase-3 (GSK-3) is a crucial protein kinase involved in numerous cellular processes.
  • Abnormal GSK-3 activation is linked to various disease pathologies, particularly cancer.
  • Recent research highlights GSK-3's role in the tumor microenvironment, influencing immune cell dynamics.

Purpose of the Study:

  • To comprehensively review the function and mechanisms of GSK-3 in the tumor microenvironment.
  • To specifically analyze GSK-3's impact on tumor-associated immune cells (TAM, NK, B, and T cells).
  • To explore the association between GSK-3 and immunological checkpoints like PD-1.

Main Methods:

  • Systematic literature review focusing on GSK-3, tumor microenvironment, and immune cells.
  • Analysis of preclinical and clinical studies investigating GSK-3 inhibitors in cancer.
  • Examination of GSK-3's signaling pathways in relation to immune modulation.

Main Results:

  • GSK-3 significantly influences the behavior and function of various immune cells within the tumor microenvironment.
  • GSK-3 activity correlates with the expression of immunological checkpoints, impacting anti-tumor immunity.
  • GSK-3 inhibitors demonstrate therapeutic potential in both hematologic malignancies and solid tumors.

Conclusions:

  • GSK-3 is a critical regulator of anti-tumor immunity and a promising therapeutic target.
  • Understanding GSK-3's intricate interactions with immune cells offers novel strategies for cancer immunotherapy.
  • Further research into GSK-3 modulation could lead to improved treatment outcomes for cancer patients.
Keywords:
GSK-3ImmunotherapyNK cellsT cellsTumor microenvironment

More Related Videos

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.1K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.4K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K