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Uveal metastasis arising from thyroid neoplasms: A case study synthesis
Mirsaeed Abdollahi1, Hooman Nateghian2, Navid Sobhi1
1Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
European Journal of Ophthalmology
|March 5, 2024
Summary
Uveal metastases from thyroid cancer (TC) are rare but significant. Physicians should consider ocular symptoms in patients with a neck mass or history of TC.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Uveal metastases are rare occurrences in patients with thyroid cancer (TC).
- Early identification and understanding of risk factors are crucial for managing these cases.
- This review synthesizes existing literature on uveal metastases from TC.
Purpose of the Study:
- To systematically review case reports of uveal metastases originating from thyroid cancer.
- To evaluate associated factors and indications for uveal metastases in TC.
- To provide clinical insights based on recent case studies.
Main Methods:
- Comprehensive literature search of Web of Science, Medline, and Scopus databases.
- Inclusion of case reports or series on uveal metastasis from thyroid neoplasms up to November 2022.
- Quality assessment using the JBI Critical Appraisal Checklist for Case Reports.
Main Results:
- Analysis of 46 cases from 43 studies, with a mean age at diagnosis of 58.44 years.
- Choroidal involvement was the most frequent presentation (84.8%).
- Papillary (34.8%), follicular (32.6%), and medullary (21.7%) carcinomas were the predominant TC types.
Conclusions:
- Uveal metastases can occur in the context of metastatic thyroid cancer.
- Ocular symptoms warrant cautious evaluation in patients with a neck mass or prior TC history.
- Increased clinical suspicion is recommended for prompt diagnosis and management.
