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Red Cell Distribution Width is Related to Mild Cognitive Impairment: A Cross-Sectional Study of Community Residents

Juan Yang1, Haijing Sui2, Haihan Song3

  • 1Department of Neurology, Shanghai Pudong New Area People's Hospital, Shanghai, China.

Neurology India
|March 5, 2024
PubMed
Abstract

Insights

Red cell distribution width (RDW) is a potential biomarker for mild cognitive impairment (MCI). Increased RDW showed a significant negative correlation with attention in MCI patients, suggesting its role in cognitive decline.

Area of Science:

  • Gerontology
  • Neurology
  • Hematology

Background:

  • Red cell distribution width (RDW) is linked to Alzheimer's disease (AD).
  • The association between RDW and mild cognitive impairment (MCI) remains unclear.
  • This study focuses on elderly residents in Shanghai, China.

Purpose of the Study:

  • To investigate the correlation between RDW and MCI in older adults.
  • To identify potential biomarkers for early detection of cognitive impairment.

Main Methods:

  • 550 participants (226 MCI, 284 normal controls) aged ≥65 were recruited.
  • Blood routine indexes, including RDW, were analyzed using Sysmex XT-4000i.
  • Statistical analyses included Chi-square, t-test, and linear regression.

Main Results:

  • MCI patients exhibited impairments across cognitive domains, with attention being the most affected (88.3%).
  • RDW showed the strongest negative correlation with attention scores in the MCI group (P < 0.05).
  • Attention impairment had the highest weight among cognitive domains in MCI.

Conclusions:

  • Elevated RDW may serve as a potential biomarker for mild cognitive impairment.
  • RDW's negative correlation with attention highlights its role in cognitive function decline.
  • Further research can explore RDW's utility in diagnosing and monitoring MCI.

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