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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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  3. Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-lymphocyte Ratio And Long-term Prognosis Of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma.
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  3. Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-lymphocyte Ratio And Long-term Prognosis Of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma.

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Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-Lymphocyte Ratio and

Kouki Imaoka1, Masahiro Ohira2, Minoru Hattori3

  • 1Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Transplantation Proceedings
|March 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

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High postoperative neutrophil-to-lymphocyte ratio (NLR) after liver transplant indicates poor survival. Immunotherapy with natural killer (NK) cells may improve outcomes by lowering NLR.

Area of Science:

  • Hepatology
  • Immunology
  • Oncology

Background:

  • Preoperative neutrophil-to-lymphocyte ratio (NLR) is a prognostic indicator in malignancies.
  • The impact of postoperative NLR on living donor liver transplant (LDLT) recipients is not well understood.
  • Immunotherapy with donor liver-derived activated natural killer (NK) cells may influence postoperative immune responses.

Purpose of the Study:

  • To clarify the clinical significance of postoperative NLR in LDLT recipients with hepatocellular carcinoma (HCC).
  • To assess if immunotherapy improves postoperative NLR and patient prognosis.

Main Methods:

  • Retrospective study of LDLT recipients (2001-2022).
  • Evaluation of postoperative NLR at 4 weeks post-transplant.
  • Correlation analysis between postoperative NLR and NK cell activation markers.

Main Results:

  • Higher postoperative NLR was associated with lower preoperative NLR, higher MELD scores, and increased early infection rates.
  • Postoperative high NLR and lack of immunotherapy were independent risk factors for poor overall survival.
  • NK cell activation markers inversely correlated with decreased postoperative NLR.

Conclusions:

  • Elevated postoperative NLR is independently linked to poor prognosis in LDLT recipients with HCC.
  • Immunotherapy utilizing activated NK cells shows potential to improve postoperative NLR and long-term survival.