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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

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Related Experiment Video

Updated: Jul 1, 2025

Transuterine Fetal Tracheal Occlusion Model in Mice

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Does early prostacyclin therapy decrease extracorporeal life support use in infants with congenital diaphragmatic

Jane Huang¹, Philippe Friedlich², Molly Crimmins Easterlin²

¹Division of Neonatology, Department of Pediatrics, Los Angeles General Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. janehuang@chla.usc.edu.

Journal of Perinatology : Official Journal of the California Perinatal Association

|March 5, 2024

Summary

No abstract available in PubMed .

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