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Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer's disease mouse model via suppressing ferroptosis

  • 0Department of Pharmacology, China Pharmaceutical University, Nanjing, China.
Phytotherapy Research : Ptr +

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March 5, 2024

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March 5, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Curculigoside (CUR) shows promise in treating Alzheimer's disease (AD) by inhibiting ferroptosis, a key factor in neuronal damage. This natural compound improved cognitive function and reduced disease markers in AD mouse models.

Area Of Science

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background

  • Alzheimer's disease (AD) is linked to ferroptosis-induced oxidative stress, causing neuronal damage and cognitive decline.
  • Identifying novel therapeutic targets and agents is crucial for effective AD treatment.

Purpose Of The Study

  • To investigate Curculigoside (CUR) as a potential therapeutic agent for Alzheimer's disease.
  • To determine if CUR can ameliorate AD by inhibiting ferroptosis and targeting key regulatory proteins.

Main Methods

  • Weighted gene co-expression network analysis (WGCNA) to identify therapeutic targets (GPX4, SLC7A11).
  • In vivo studies using scopolamine and okadaic acid (OA)-induced AD mouse models.
  • In vitro studies on neuronal cells exposed to OA and scopolamine neurotoxicity.
  • Analysis of AD and ferroptosis markers, and key protein expressions (GPX4, SLC7A11, GSH/GSSG ratio).

Main Results

  • CUR administration ameliorated cognitive impairment in AD model mice.
  • CUR protected neuronal cells in vitro by modulating ferroptosis markers.
  • CUR reduced levels of amyloid-beta (Aβ<sub>1-42</sub>) and phosphorylated tau (p-tau) in AD mice.
  • CUR up-regulated GPX4 and down-regulated SLC7A11, increasing the GSH/GSSG ratio, indicating ferroptosis inhibition.

Conclusions

  • Curculigoside (CUR) demonstrates therapeutic potential for Alzheimer's disease.
  • CUR ameliorates AD by inhibiting ferroptosis through modulation of the GPX4 and SLC7A11 pathway.
  • CUR represents a promising natural compound for AD treatment, warranting further investigation.

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