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Related Concept Videos

Capillaries and Their Types01:20

Capillaries and Their Types

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Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists,...
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Blood Flow01:29

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Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
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Capillary Exchange01:28

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The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
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Flow Cytometry01:23

Flow Cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Laminar Flow01:27

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Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
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Related Experiment Video

Updated: Jul 1, 2025

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
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Cells flowing to attain functionality.

Martín G Bellino1

  • 1Instituto de Nanociencia y Nanotecnología (INN), Comisión Nacional de Energía Atómica (CNEA) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Biology of the Cell
|March 6, 2024
PubMed
Summary

Investigating microscale cell flow reveals how cellular functions originate. The interplay between cells and microcirculation offers new insights into complex cell biology.

Area of Science:

  • Cell Biology
  • Biophysics
  • Physiology

Background:

  • Understanding fundamental biological processes governing cell functions is a significant scientific challenge.
  • Cellular behavior and functions are intricate and not fully understood.
  • Microscale phenomena play a crucial role in biological systems.

Purpose of the Study:

  • To explore microscale cell flow as a potential source of cellular functionality.
  • To provide an outlook on the significance of cell-microcirculation interactions.
  • To highlight how studying these interactions can advance cell biology.

Main Methods:

  • This is a commentary, not an experimental study.
  • Literature review and theoretical analysis of existing research.

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  • Conceptual framework development for cell-microcirculation interplay.

    • Main Results:

    • Microscale cell flow is proposed as a key factor in the genesis of cell functionality.
    • The interaction between cell dynamics and microcirculation offers a novel perspective.
    • This interplay is crucial for understanding complex cellular behaviors.

    Conclusions:

    • The study of microscale cell flow and its relationship with microcirculation is essential for advancing cell biology.
    • Future research focusing on this interplay promises significant discoveries.
    • This approach can unlock deeper insights into the complexity of cell biology.