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Updated: Jul 1, 2025

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BOIN-ETC: A Bayesian optimal interval design considering efficacy and toxicity to identify the optimal dose

Tomoyuki Kakizume1, Kentaro Takeda2, Masataka Taguri3

  • 1Takeda Pharmaceutical Company Limited, Japan.

Statistical Methods in Medical Research
|March 6, 2024
PubMed
Abstract

Keywords:
Bayesian adaptive dose-finding designdrug combinationefficacy-toxicitymodel-assisted designwaterfall approach

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