Related Experiment Video
Updated: Jul 1, 2025

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Direct induction onto high-dose long-acting injectable buprenorphine: A case series
Thileepan Naren1,2, Jon Cook1,2, Paul MacCartney3
1Drug Health Services, Western Health, Footscray, AU-VIC, Australia; and.
Introduction:
This case series reports on five patients with opioid use disorder (OUD) who were commenced directly onto high-dose long-acting injectable buprenorphine (LAIB).
Method:
A retrospective audit and manual review of the electronic medical record at cohealth Innerspace was conducted for patients who had been directly inducted onto high-dose LAIB.
Results:
Five cases were identified on retrospective manual file review. All patients identified were males aged between 33 and 60 years old and were treated with either high-dose Buvidal Weekly and Monthly preparations. No immediate significant adverse effects were noticed and 4 out of 5 remain engaged with treatment.
Conclusion:
This case series shows it is possible to directly induct patients with OUD onto high-dose LAIB preparations without significant side effects or harm to the patient and could be considered a viable option in the treatment of patients with OUD.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Desensitization and Tachyphylaxis
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Drug Abuse and Addiction: Pharmacological Phenomena

