The recent advance and prospect of natural source compounds for the treatment of heart failure

Area of Science:

• Cardiology
• Pharmacology
• Natural Products Research

Background:

• Heart failure is a progressive syndrome of cardiac insufficiency, a major global health concern and leading cause of death in cardiovascular disease patients.
• Complex pathophysiological mechanisms, including hemodynamic abnormalities and myocardial remodeling, underlie heart failure symptoms like dyspnea and fatigue.
• Current treatments involve cardiac glycosides, diuretics, ACE inhibitors, vasodilators, and beta-blockers, but natural products present unique advantages.

Purpose of the Study:

• To review recent advancements in the mechanisms and active ingredients of natural products for treating heart failure.
• To highlight the therapeutic potential of natural products in managing cardiac insufficiency.
• To inspire the development of novel, potent clinical drugs for heart failure based on natural sources.

Main Methods:

• Literature review focusing on natural products and their active compounds relevant to heart failure.
• Analysis of mechanisms of action for identified natural products.
• Synthesis of recent research findings on efficacy and safety profiles.

Main Results:

• Natural products exhibit mild efficacy, low toxicity, and multi-target comprehensive effects beneficial for heart failure.
• Active ingredients from natural sources show potential in restoring cardiac function and improving quality of life.
• Natural products can help reduce energy disorders associated with heart failure.

Conclusions:

• Natural products represent a valuable resource for developing new heart failure therapies.
• Further research into natural product mechanisms and active ingredients can lead to improved treatments for cardiac insufficiency.
• The unique advantages of natural products offer a promising direction for future drug discovery in cardiology.