Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Theranostics

Background:

• Magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH) enable localized hyperthermia and imaging-assisted thermometry.
• Current MPI-MFH platforms require separate systems and object transfer, limiting efficiency.
• Integrating MFH functionality into existing MPI scanners offers a more streamlined approach.

Purpose of the Study:

• To design, develop, and evaluate integrable MFH platforms compatible with commercial MPI scanners.
• To overcome the challenge of magnetic coupling between MFH and MPI systems.
• To enable MPI-guided, spatially selective magnetic hyperthermia therapy.

Main Methods:

• Developed integrable MFH platforms designed to extend a commercial MPI scanner.
• Employed a self-compensation approach using heuristic algorithms to mitigate magnetic coupling issues.
• Evaluated electrical/magnetic characteristics, cooling, field strength, magnetic coupling, and particle heating.

Main Results:

• The MFH platforms generate suitable magnetic fields for particle heating and are compatible with MPI scanners.
• Selective heating with gradient fields and steerable heating positioning using MPI focus fields were achieved.
• The integration successfully protected the MPI scanner from harmful induced voltages.

Conclusions:

• The developed MFH platforms integrate seamlessly with commercial MPI scanners, enabling MFH functionality.
• This integrated system facilitates MPI-guided, spatially selective magnetic hyperthermia therapy.
• The approach paves the way for future preclinical trials of advanced hyperthermia treatments.