Related Experiment Video
Updated: Jul 1, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
Successful heart transplantation from a COVID-19-positive donor: A clinical case report
Mohsen Meidani1, Maryam Moradi2, Fereshteh Ghiasvand3
1Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Insights
Heart transplants from donors positive for COVID-19 are feasible, but more long-term research is necessary. This study details the outcomes of such a critical procedure during the pandemic.
Area of Science:
- Cardiology
- Infectious Diseases
- Transplantation Medicine
Background:
- The COVID-19 pandemic created significant challenges for organ transplantation.
- Concerns exist regarding the safety and efficacy of using organs from donors infected with SARS-CoV-2.
Observation:
- This study investigated the outcome of a heart transplant procedure utilizing an organ donor who tested positive for COVID-19.
- The study aimed to characterize the results and implications of such a transplant.
Findings:
- The heart transplant recipient from a COVID-19-positive donor showed acceptable initial results.
- This suggests that transplantation may be a viable option even with donor-recipient COVID-19 status considerations.
Implications:
- While initial outcomes are promising, further extensive studies with longer follow-up periods are required.
- These studies will provide more definitive conclusions on the long-term viability and safety of transplanting organs from COVID-19-positive donors.
Key Clinical Message:
Despite the acceptable results in patients receiving organs from COVID-19-positive donors, more extensive studies over a longer period are still needed for more accurate conclusions.
Abstract:
Organ transplantation is a major concern during the current COVID-19 pandemic worldwide. The use of COVID-19-positive organ donors has raised widespread concerns in the field of transplantation. In this study, we characterized the outcome of a heart transplant from an organ donor positive for COVID-19.

