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Published on: October 4, 2019
Four new isocoumarins from Cajanus cajan
Liyuan Yao1,2,3, Aikebaier Jumai1,2, Xiaobao Huang1,4
1State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Program for Natural Product Chemical Biology Guangzhou 510650 China sxqiu@scbg.ac.cn +86-20-37081190 +86-13924031914.
Abstract:
Four novel new isocoumarins, cajanolactone B, C, D1 and D2 (1-4), were isolated from ethanolic extracts of the leaves of Cajanus cajan. The structural elucidation has been completed mainly depending on extensive spectroscopic analysis including UV, IR, NMR (1D and 2D), HRESIMS and chiral analysis. Notably, all these new isocoumarins were found to exist in racemic forms, among which compounds 3 and 4 share the same planar structure. This finding suggests that at least the biosynthesis of isocoumarin in C. cajan is chiral tolerant. A plausible biogenetic pathway of compounds 1-4 is proposed.
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